In Silico Prediction and Functional Validation of σ28-Regulated Genes in Chlamydia and Escherichia coli
HHY Yu, D Kibler, M Tan - Journal of bacteriology, 2006 - Am Soc Microbiol
ABSTRACT σ28 RNA polymerase is an alternative RNA polymerase that has been
proposed to have a role in late developmental gene regulation in Chlamydia, but only a
single target gene has been identified. To discover additional σ28-dependent genes in the
Chlamydia trachomatis genome, we applied bioinformatic methods using a probability
weight matrix based on known σ28 promoters in other bacteria and a second matrix based
on a functional analysis of the σ28 promoter. We tested 16 candidate σ28 promoters …
proposed to have a role in late developmental gene regulation in Chlamydia, but only a
single target gene has been identified. To discover additional σ28-dependent genes in the
Chlamydia trachomatis genome, we applied bioinformatic methods using a probability
weight matrix based on known σ28 promoters in other bacteria and a second matrix based
on a functional analysis of the σ28 promoter. We tested 16 candidate σ28 promoters …
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